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How Chronic Stress can Shrink the Brain

Updated: Jun 13, 2021

Life is full of excitement and possibilities. There are so many things that make

us laugh and treasure.

However, sometimes stress in various forms is inevitable in our daily life.

Stress may not necessarily be a bad thing, stress can help us focus and drive

us to perform better.

One example is when we are going for a job interview, we stress about it so that we prepare and present our best to the panel in order to win the job.

Unfortunately, when stress is ongoing and persistent, it can produce undesirable negative effects and it can shrink the size of our brain.

Stress and Cortisol

When we are under stress, the body will produce a chemical called cortisol

which is the primary stress hormone. Cortisol makes us fight or flight to deal

with the situation. With continual influx of cortisol in our body, it can drive a

cascade of undesirable and detrimental effects on our brain.

Chronic Stress Effects on the Brain:

Chronic Stress | Wellbeing Physiotherapy Leederville

Amygdala is the fear centre of the brain. High levels of cortisol will increase

the activity level and number of neural connections in this area. Amygdala and hippocampus can become better connected, making fear response much

quicker than usual.


It is the area of the brain associated with our learning, memory and stress

control. High levels of cortisol can cause electrical signals between neurons

to deteriorate and inhibit the formation of nerve cells and decrease the size of

hippocampus. This in turn can weaken our ability to control stress.

Prefrontal Cortex

Too much cortisol can shrink the size of the brain, through the loss of synaptic

connection between neurons, especially in the pre-frontal cortex of the brain.

The prefrontal cortex regulates complex cognitive behaviour, personality

expression, decision making, judgment and social interactions.

Mental Health Impact

With ongoing stress, we lose the ability to regulate our fear and it make us

more vulnerable to develop into depression, anxiety and Alzheimer’s diseases

later in life.

Next time, we will talk about ways to help alleviate chronic stress.


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